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Connell, Philip P.
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overview Philip Connell, MD, is an expert in radiotherapy with a particular focus on sarcomas, thoracic cancers, and pediatric malignancies. This year he was again recognized by Newsweek as one of “America's Top Doctors” and by Chicago Magazine as a “Top Doctor” in the Chicagoland region. In addition to his clinical responsibilities, Dr. Connell is an active cancer researcher. He received laboratory training in cancer biology through a National Cancer Institute fellowship. His oncology research program is working to identify molecular markers of treatment resistance and to develop new anti-cancer agents that can overcome these molecular hurdles. His newest ongoing projects involve several novel, high-throughput assays designed to identify potential drugs that modify DNA repair. With these systems, researchers have the potential to discover new chemical compounds with wide-ranging impacts--from improving present oncology therapies to blocking the mutagenic effects of chemotherapy and radiotherapy. Dr. Connell has received several awards including the American Society of Clinical Oncology Merit Award, American Brachytherapy Society Research Award, Roentgen Society Research Award, Samuel Hellman Teacher of the Year Award, and American Society for Therapeutic Radiology and Oncology Junior Faculty Fellowship Award. He has authored numerous medical reports and textbook chapters, and he serves as a reviewer for numerous medical journals.
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Concept Adenocarcinoma
Concept Adenoviridae
Concept Age Factors
Concept Actuarial Analysis
Concept Antibiotics, Antineoplastic
Concept Aged, 80 and over
Concept Awareness
Concept Adolescent
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Concept Amino Acid Sequence
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Concept Analysis of Variance
Concept Benzamides
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Concept China
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Concept Attitude to Health
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Concept DNA-Binding Proteins
Concept DNA Repair
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Concept Neoplasms, Multiple Primary
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Concept Orthopedics
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Concept Female
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Concept Rec A Recombinases
Concept Guanine
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Concept 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Concept History, 21st Century
Concept Tumor Burden
Concept Carcinoma, Large Cell
Concept Area Under Curve
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Cell Cycle Proteins
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Concept Platinum
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Concept Sarcoma
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Concept PTEN Phosphohydrolase
Concept Rad51 Recombinase
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Concept HIV Integrase
Concept History, 20th Century
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Concept Homologous Recombination
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Concept History, 19th Century
Concept Replication Protein A
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Academic Article One versus two intracavitary brachytherapy applications in early-stage cervical cancer patients undergoing definitive radiation therapy.
Academic Article Acute problems during low-dose-rate intracavitary brachytherapy for cervical carcinoma.
Academic Article What is the optimal treatment volume in Hodgkin's disease patients undergoing high-dose chemotherapy and adjuvant radiation therapy?
Academic Article Analysis of the role of adjuvant chemotherapy for invasive carcinoma of the esophagus.
Academic Article Equivalent racial outcome after conformal radiotherapy for prostate cancer: a single departmental experience.
Academic Article Outcome of endometrial carcinoma patients with involvement of the uterine serosa.
Academic Article Gene therapy: the challenges of translating laboratory research into clinical practice.
Academic Article The Yin and Yang of treating BRCA-deficient tumors.
Academic Article A hot spot for RAD51C interactions revealed by a peptide that sensitizes cells to cisplatin.
Academic Article Relevance and irrelevance of DNA damage response to radiotherapy.
Academic Article Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers.
Academic Article Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy.
Academic Article Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers.
Academic Article Pathologic response rates following definitive dose image-guided chemoradiotherapy and resection for locally advanced non-small cell lung cancer.
Academic Article A chemical compound that stimulates the human homologous recombination protein RAD51.
Academic Article Advances in radiotherapy and implications for the next century: a historical perspective.
Academic Article Stimulation of the human RAD51 nucleofilament restricts HIV-1 integration in vitro and in infected cells.
Academic Article Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease.
Academic Article Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer.
Academic Article RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.
Academic Article Surgery and postoperative radiation therapy in stage II endometrial carcinoma.
Academic Article Do conventional pathologic features lose their prognostic significance following postoperative radiation therapy in pathologic stage I-II endometrial adenocarcinoma?
Academic Article Significant pelvic recurrence in high-risk pathologic stage I--IV endometrial carcinoma patients after adjuvant chemotherapy alone: implications for adjuvant radiation therapy.
Academic Article Surgery and postoperative radiation therapy in FIGO Stage IIIC endometrial carcinoma.
Academic Article A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer.
Academic Article A downside to apoptosis in cancer therapy?
Academic Article The significance of adnexal involvement in endometrial carcinoma.
Academic Article Long term follow up of nasolacrimal intubation in adults.
Academic Article Radiotherapy for pediatric brain tumors: when and how.
Academic Article An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
Academic Article Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing.
Academic Article Small molecule derived from a natural product that mitigates radiation injury.
Academic Article RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
Academic Article The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
Academic Article DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy.
Academic Article Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration.
Academic Article Investigating ethnic differences in sexual health: focus groups with young people.
Academic Article Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51.
Academic Article Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?
Award or Honor Receipt American Society for Therapeutic Radiology and Oncology Junior Faculty
Academic Article A phase I dose-escalating study of combination pemetrexed-based chemotherapy and concomitant radiotherapy for locally advanced or metastatic non-small cell lung or esophageal cancer.
Academic Article Low Recombination Proficiency Score (RPS) Predicts Heightened Sensitivity to DNA-Damaging Chemotherapy in Breast Cancer.
Academic Article Impact of Cardiac Dose on Cardiac Events and Survival in Unresectable Lung Cancer Patients.
Academic Article Effect of Endoscopic Bronchial Ultrasound on Outcomes for Stage I Non-Small-Cell Lung Cancer Patients Receiving Hypofractionated Radiotherapy.
Academic Article Optimization of Drug Candidates That Inhibit the D-Loop Activity of RAD51.
Award or Honor Receipt Recognized as one of “America's Top Doctors”
Award or Honor Receipt Recognized as a “Top Doctor”
Grant RAD51 Inhibitors for Chemotherapy and Radiation Therapy
Grant Inhibition of Recombination DNA Repair in Pancreatic Cancer Cells
Academic Article Heart V5 predicts cardiac events in unresectable lung cancer patients undergoing chemoradiation.
Academic Article Radiation-Induced Sarcoma After Heterotopic Ossification Prophylaxis: A Case Report.
Academic Article CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.
Academic Article Targeting Non-Canonical NF?B2 to Determine the Effects on Radiation Sensitization.
Academic Article qRT-PCR-based DNA homologous recombination-associated 4-gene score predicts pathologic complete response to platinum-based neoadjuvant chemotherapy in triple-negative breast cancer.
Academic Article Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination.
Academic Article Noncanonical NF-?B factor p100/p52 regulates homologous recombination and modulates sensitivity to DNA-damaging therapy.
Academic Article STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non-Small-Cell Lung Cancer.
Academic Article Team Approach: Management of Pathologic Fractures.
Concept Pemetrexed
Concept Loss of Function Mutation
Concept Cycloaddition Reaction
Concept MCF-7 Cells
Concept Ataxia Telangiectasia Mutated Proteins
Concept Heterografts
Concept Triple Negative Breast Neoplasms
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